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This Concept Map, created with IHMC CmapTools, has information related to: Biochem A1 Hyperhomocysteinemia, homocysteine causing stroke, methionine adenosyltransferase (MAT) to s-adenosylmethionine (SAM), endothelial tissue leading to dysfunction of endothelium blood vessels, methionine is converted by methionine adenosyltransferase (MAT), methionine synthase reductase (MTRR) decreased intermediates of folate cycle (THF), methylenetetrahydrofolate reductase (MTHFR) preventing conversion of homocysteine, methionine metabolism lead to elevated homocysteine, betaine to dimethyl glycine (DMG), defect in gene for methionine synthase reductase (MTRR), H2O2 leading to dysfunction of endothelium blood vessels, 5,10 methylenetetrahydrofolate (5,10-MTHF) is converted by methylenetetrahydrofolate reductase (MTHFR), methylenetetrahydrofolate reductase (MTHFR) to 5-methyltetrahydrofolate (5-MTHF), defects in methionine metabolism, stroke-like symptoms leads to genetic testing, serine to glycine, serine to cystathionine, homocysteine to methionine, methyl transferase (MTs) to S-adenosylhomocystenine (SAH), cobalamin is cofactor for methionine synthase (MS), pyridoxal phosphate (PLP) to cysteine